SFU Undergraduate Researcher: Deveshi Deveshi

Introducing Deveshi Deveshi from the Faculty of Health Sciences!

Name: Deveshi Deveshi
Year: 3rd 
Major: Health Sciences, Life Sciences Stream
Supervisor: Dr. Gratien Prefontaine

Q: What do you want to be when you grow up?
A:
I want to work in the healthcare system, preferably in medicine as a physician.

Q: How did you get involved in research?
A:
Initially, I became interested in research by learning about the various research projects done in different faculties at SFU, especially in the Faculty of Health Sciences. Getting involved in research seemed as a great learning experience through which I could learn as well as apply my knowledge. So in my second year, I decided to contact various researchers to apply for research positions. However, I had very limited experience in working in a lab setting and most research projects did not have positions open so I didn’t get much response. Thankfully, Dr. Prefontaine invited me to join his Epigenetics Lab and so I got a summer USRA to conduct research in his lab.

Q: What are you researching?
A:
Dr. Prefontaine’s Lab focuses on the role of SmcHD1, an epigenetic chromatin remodeling protein, in gene expression and control. Over the Summer semester, I read various research papers on the topic and worked on creating different BAC plasmids with the SmcHD1 gene insert in order to use the Baculovirus Expression System which is a method used to produce recombinant baculovirus for protein expression.

Q: What’s your favourite course that you have taken so far in your degree?
A:
BISC 202 with Dr. Fitzpatrick! That course really fascinated me. Dr. Fitzpatrick made the course even more engaging.

Q: What scares you the most in the lab or the field? 
A:
We had limited amount of the gene of focus so various procedures and experiments had to be done quite carefully and precisely. Initially, that was a bit scary but you learn as you go!

Q: How did you get involved in research?
A:
Initially, I became interested in research by learning about the various research projects done in different faculties at SFU, especially in the Faculty of Health Sciences. Getting involved in research seemed as a great learning experience through which I could learn as well as apply my knowledge. So in my second year, I decided to contact various researchers to apply for research positions. However, I had very limited experience in working in a lab setting and most research projects did not have positions open so I didn’t get much response. Thankfully, Dr. Prefontaine invited me to join his Epigenetics Lab and so I got a summer USRA to conduct research in his lab.

Q: What are you researching?
A:
Dr. Prefontaine’s Lab focuses on the role of SmcHD1, an epigenetic chromatin remodeling protein, in gene expression and control. Over the Summer semester, I read various research papers on the topic and worked on creating different BAC plasmids with the SmcHD1 gene insert in order to use the Baculovirus Expression System which is a method used to produce recombinant baculovirus for protein expression.

Q: What’s your favourite course that you have taken so far in your degree?
A:
BISC 202 with Dr. Fitzpatrick! That course really fascinated me. Dr. Fitzpatrick made the course even more engaging.

Q: What scares you the most in the lab or the field? 
A:
We had limited amount of the gene of focus so various procedures and experiments had to be done quite carefully and precisely. Initially, that was a bit scary but you learn as you go!

Acknowledgements to my Mentors

By Sean La

I recently finished writing my honours thesis for my Bachelor’s Degree in Mathematics. I proved that a computational problem arising in evolutionary biology is NP-hard and APX-hard, i.e. very hard to solve (probably), which was pretty cool. Along with my proofs, I’m also required to write a page of acknowledgements, thanking the people who’ve helped me along the way.

This got me thinking: as much as mathematics is beautiful and powerful, it was not a theorem that left the biggest impact on me these last four years, but two simple acts of compassion and mentorship. So here is what I wrote, slightly abridged to leave out mentions of my family and my friends, who are all very much important people, but not the focus of this post.

Acknowledgements

Many people can describe a memory that demarks their life into two distinct time periods: before and after. It may be an accomplishment, such as an academic degree or a first job, or something solemn, like the passing of a relative. For me, this defining memory is something perhaps more nerdy. But it’s significant to me nonetheless.

My memory is actually the summer of 2016, when I worked with the two of you on your various research projects. Perhaps it was not obvious at the time, but prior to that research term, I struggled with self-confidence. I had a hard time believing that I would be able to contribute much, or amount to anything. I made many mistakes that summer. But you two, you were patient and kind, but most importantly, you showed me discipline and mentorship. Because of you two, I now truly believe in my own ideas and that I do have the means to instigate positive change. Not only academically, but in all parts of my life.

I came to university wanting to become a professor, to gain the skills necessary to not only free myself from the shackles of my socioeconomic context, but to help others do the same as well. These shackles which were brought on by colonialism, duress, greed, the desire of men to have overwhelming power over others.

Four years later, I’m no more sure of whether I’ll be able to accomplish this goal. But you, my mentors, you’ve taught me a lesson more valuable than any of the theorems or algorithms I learned in class:

It doesn’t matter.

You two gave me the gift of self-confidence, the knowledge and the drive to build a meaningful future for myself and others, regardless of whether academia has a place for me. This is the most valuable lesson I’ve learned in university.

So thank you.

SFU Undergraduate Researcher: Quratulain Qureshi

Introducing Quratulain Qureshi from the department of Molecular Biology and Biochemistry!

SFU_SURJ_BLOG_Quratulain_HighResolution

Full name: Quratulain Qureshi
Year: Fourth
Major: Molecular Biology and Biochemistry
Supervisor: Dr. Ralph Pantophlet

Q: What do you want to be when you grow up?
A: I hope to enter the field of medicine, either clinical or experimental. I have always enjoyed learning about pathology and hope to pursue it as part of my career.

Q: How did you get involved in research?
A: Very early into my degree, I became fascinated by all the scientific research taking place at SFU and availed every opportunity to attend research seminars and thesis defenses to learn more. During my first year, I joined the Injury Prevention and Mobility Lab as a volunteer where we analyzed the biomechanics of fall events in older adults. I then took MBB322 and became exposed to and developed an interest in immunology topics. I did some research on SFU’s Immunology group and was fascinated with the research being done in the Pantophlet Lab. Seeing an opening, I decided to apply, and I was thrilled when I got an interview and a subsequent internship.

Q: What are you researching?
A: Research in our lab involves HIV-1 vaccine immunology and molecular vaccine design. Historically, vaccines modeled after conserved components of an infectious agent have proven to be an effective way of priming the individual’s immune system with the right tools in case of an infection. Finding these components for HIV has been a challenge due to the high mutation rate of the virus. Our lab has identified a sugar molecule (glycan) on the viral surface that exhibits a lower level of variability and is a potential candidate. My project involves probing molecules designed to mimic this glycan for binding affinity using a class of antibodies that elicits a neutralizing effect for the HIV virus. I am also studying the efficacy of these mimetics when model organisms are immunized with them.

Q: What is a typical “day in the life” in the lab for you?
A: It depends on the day, most days I perform binding assays using ELISAs or Surface Plasmon Resonance (SPR). These experiments usually take some time and have long incubations, so I try to keep myself organized and plan my day first thing when I come in (I realized how important this step is the hard way). I also carry out protein purifications using high performance liquid chromatography (HPLC) and perform various recombinant DNA techniques.

Q: What’s your favorite course that you have taken so far in your degree?
A: My favorite course so far has been MBB309W. It was my first Biochemistry Lab experience. I loved being able to perform the techniques we learned about in textbooks and it was always thrilling to analyze data after lab to see if our hours of work yielded good results.

Q: Favorite science joke or meme from your field?

Meme

 

Q: What scares you the most in the lab or the field?
A: Centrifuges. I still check multiple times to make sure everything is balanced.

We’re Recruiting!

We're recruiting! (1)

Are you interested in joining SFU SURJ’s 2018-2019 Editorial Team?

We are looking for motivated individuals who are interested in learning more about the peer-review process.

To apply, fill out this application form and email it to sfusurj@sfu.ca with the title “Editor Application 2018/2019.” Please also attach a CV or resume.

The deadline to email us your application form and CV/resume is Monday October 1st.

SFU Undergraduate Researcher: Aleksandra Dojnov

Introducing Aleksandra Dojnov from the department of Biomedical Physiology and Kinesiology!

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Name: Aleksandra Dojnov
Year: 3rd Year
Major:
Biomedical Physiology and Kinesiology
Supervisor: Dr. Stephen Robinovitch

Q: What do you want to be when you grow up/ finish undergrad?
A: The human body has always been interesting to me. I swam competitively as a kid and, because of this, spent a lot of time at the physiotherapists. I found these sessions with my physiotherapist interesting so when it came to apply for university, I applied to SFU’s Kinesiology major with the goal of becoming a physiotherapist. As I progressed through my degree, I realized I liked biomechanics and building things a lot, so I searched graduate schools related to my interests. I found a prosthetics program and have wanted to go into prosthetics since then. In the future, I hope to make neuro-prosthetics and wearable sensors.

Q: How did you get involved in research?
A: Last September I started volunteering in the IPML lab. This opportunity got me more interested in research so, when I started applying for co-op jobs, I decided to apply for an 8-month co-op in the lab. I ended up getting the job and, as part of my co-op, I get the opportunity to work on a research project.

Q: What are you researching?
A: We are looking at the associations between fall characteristics of older adults in long-term care facilities and their injury patterns. Previous research has investigated either the associations between impact and other fall characteristics or between fall characteristics and injury patterns using data collected from the faller, but this has not been very accurate. We’re looking into injury patterns using data collected via video camera footage, so our data should produce new, and more accurate, results.

Q: Favourite science joke or meme from your field?

MEME

Q: What scares you the most in the lab or the field?
A: What both excites and scares me the most in my field is the direction we’re heading towards creating cyborgs. The equipment available to enhance the human body is rapidly improving. With these quick advances in technology, it may become hard to use technology only for good. I think we may be seeing a hopefully benevolent, cyborg in the very near future.

SFU Graduate Researcher: Shabnam Massah

Thinking about embarking in graduate school? SURJ is starting a new blog series that features SFU graduate students and professors. For our first entry, we’re excited to introduce Shabnam Massah who completed her PhD in the Faculty of Health Sciences.

Shabnam Massah

Name: Shabnam Massah
Faculty: Health Sciences
Post graduate education: PhD at SFU.

Q: What is the most exciting thing about being in research? What do you love about research? 
A: I get to examine, learn, ask, and test fundamental and basic concepts of life, then come up with a hypothesis for life. I can come up with a hypothesis based on preliminary observations and design experiments to test them. I also get to exercise problem solving skills everyday and that is rewarding to me. There are also opportunities to think outside the box to solve the problem. When I die, I want to make sure I at least made one  improvement in science or someone’s life.

Q: What do you dislike most about research?
A: Even though 90% of the time it doesn’t work, the 10% is like the light at the end of the tunnel. The encouragement you get from good results makes you go. You need to be determined and really enjoy it to be in research.

Q: How did you get involved in research?
A: I always knew I wanted to do research but not until after undergrad because I never had the chance to work in a research lab then. When I immigrated to Canada I looked for this opportunity. I started taking some courses at UBC and volunteering at SFU. After six months, things just clicked.

Q: What are your research interests?
A: I am interested in epigenetics. I study how chemical modifications of DNA and histone proteins can change chromatin structure and DNA accessibility, and therefore gene expression. I’m interested to see how these chemical modifications are added and recognized by certain proteins that eventually can change gene expression. Things we experience, things we eat, what we feel can all change gene expression and that is the power of epigenetics.

Q: What is a typical “day in the life” for you?
A: I have different duties. I have been an instructor, a lab instructor, TA-ships, working on my project as a PhD student. Part of teaching is meeting students, helping them out. I direct and guide undergraduate students in the lab. I read and research and write grants. I’m a mom and wife so I have a lot to do. I also instruct piano twice a week.

Q: Favourite science joke or meme from your field?
A: If you’re not part of the solution you’re part of the precipitate.

Q: If you were a scientific lab instrument, which one would you be?
A: A pipetman (automatic pipette) because it’s with you from the beginning of the experiment to the end. It’s there for you in good experiments and bad.

Q: Who is your biggest science crush?
A: Madam Curie because she devoted her whole life [to science]. She was the first female to win a nobel prize and the first person to win it twice.

Q: What is fun about the lab?
A: Our lab has an open lab structure so it is connected to three other labs. I made a lot of friends during my graduate studies and it was fun having an open concept. We could talk about research, borrow materials, and it was good to know you have someone there for you.

Q: What scares you the most in the lab or in your field?
A: When you are at the last steps of an experiment that took you three weeks to do and an instrument breaks down. It is the worst feeling in the world. Sometime the samples are really precious, takes months to collect, and when an instrument breaks at the last minute, it’s not fun.

Q: What is one piece of advice you would give to an aspiring undergraduate researcher?
A: Volunteer, do co-op. I wish I had these opportunities in my undergrad. Students here are so lucky to have the coop program and have opportunities to volunteer. But you need to take your job seriously if you’re in the lab. I have lots of students come to work just to fill out their med applications or get a reference letter. They did not survive because their mindset was wrong but those who [were genuinely interested] and determined did great. Work hard. Take advantage of your time. It’s precious.

SFU Undergraduate Researcher: Nick Gauthier

Introducing Nick Gauthier from the department of Biology!

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Name: Nick Gauthier
Year: 4th Year
Major:
Biology
Supervisor: Dr. Margo Moore

Q: What do you want to be when you grow up/ finish undergrad?
A: I hope to be accepted into medical school and become a practicing physician after I complete my undergrad. I’m really interested in infectious diseases, which is why I wanted to become involved in the Moore Lab.

Q: How did you get involved in research?
A: I took BISC 303 with Dr. Moore and really enjoyed the course so I decided to email her and ask if there were any positions to volunteer in the lab. She responded and agreed to meet with me. I met with all of the lab members for lunch one day and everyone was extremely friendly! I started volunteering in the lab in January and am currently holding a USRA for the summer semester.

Q: What are you researching?
A: So far, I have worked on several projects, but I am currently attempting to purify a sialidase enzyme in the human pathogenic fungus Aspergillus terreus. Sialidases cleave sialic acid and play a key role in microbial pathogenesis. We believe that the Aspergillus terreus sialidase plays a role in human pathogenesis and are looking to find out more about its’ substrate specificity and how it works.

Q: What is a typical “day in the life” in the lab for you?
A: Because the project I am working on requires many steps and lengthy procedures, there really isn’t a typical “day in the lab”, which I really enjoy about working in the lab because every day is something new for the most part.

Q: What’s your favourite course that you have taken so far in your degree?
A: There have been a few courses that I’ve really enjoyed, but I think my favorite was the course I took at the Bamfield Marine Sciences Centre last summer; Marine Invertebrate Zoology. The atmosphere in Bamfield is like nowhere else in the world and I met a lot of cool people in my class. In fact, one of my classmates from Bamfield works in the Moore Lab with me now and helped train me!

Q: Favourite science joke or meme from your field?

Nick_meme

Q: If you were a scientific lab instrument, which one would you be?
A: Honestly, I think that I would be a centrifuge because my mind is constantly spinning!

Q: What scares you the most in the lab or the field?
A: At first, I was really scared about messing up in the lab and making mistakes, but as a became more familiar with everyone I was more open to asking questions and help. Everyone in the lab has been so awesome and willing to help whenever I ask!